C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2727839
The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit mono-clonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
La présente invention concerne des agents de liaison immunologique anti-VEGF solubles et stables qui comprennent des CDR issus d'anticorps monoclonaux de lapin. Lesdits anticorps sont conçus pour le diagnostic et/ou le traitement de troubles à médiation assurée par le VEGF. L'invention concerne également des hybridomes, acides nucléiques, vecteurs et cellules hôtes pour l'expression des anticorps de recombinaison de l'invention, des méthodes pour isoler ceux-ci et l'utilisation desdits anticorps dans le domaine médical.
Borras Leonardo
Gunde Tea
Urech David
Esbatech An Alcon Biomedical Research Unit Llc
Smart & Biggar
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