Stable antibody formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 9/08 (2006.01) C07K 16/26 (2006.01)

Patent

CA 2681743

The present invention provides formulations and methods for the stabilization of antibodies. In one embodiment, the invention provides the stable solution formulation of an IgG1 antibody that specifically binds to insulin-like growth factor-I receptor. In another embodiment, the invention provides methods of stabilization of IgG1 antibody that specifically binds to insulin-like growth factor-I receptor comprising lyophilizing an aqueous formulation of the antibody. The formulations can be lyophilized to stabilize the antibodies during processing and storage, and then the formulations can be reconstituted for pharmaceutical administration.

La présente invention concerne des formulations et des procédés permettant la stabilisation des anticorps. Dans un mode de réalisation, l'invention concerne la formulation en solution stable d'un anticorps IgG1 qui se lie spécifiquement à un récepteur de facteur de croissance I de type insuline. Dans un autre mode de réalisation, l'invention concerne des procédés de stabilisation de l'anticorps IgG1 qui se lie spécifiquement à un récepteur de facteur de croissance I du type insuline comprenant la lyophilisation d'une formulation aqueuse de l'anticorps. Les formulations peuvent être lyophilisées pour stabiliser les anticorps pendant un traitement et un stockage, puis les formulations peuvent être reconstituées pour une administration pharmaceutique.

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