Stable aqueous pharmaceutical composition comprising tezosentan

Details Stable aqueous pharmaceutical composition comprising tezosentan Stable aqueous pharmaceutical composition comprising tezosentan

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 9/08 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2308660

Difficulties in preparing a stable pharmaceutical composition containing 5- Isopropyl-pyridine-2- sulfonic acid 6-(2-hydroxy-ethoxy)-5(2-methoxy- phenoxy)2-(2-1H-tetrazol-5-yl- pyridin-4yl)- pyrimidin-4-ylamide in form of the water soluble disodium salt, a buffer and preferably a metal complex forming agent, have been encountered. It was unexpectedly found that these difficulties can be overcome by adjusting the pH of the solution with an acid to over and above 8,2, preferably to 9,0, but not higher than 10.

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