Stable ascorbic acid compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/375 (2006.01) A61K 8/67 (2006.01) A61K 8/73 (2006.01) A61K 47/10 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2054189

A stable topical composition consists essentially of at least about 1 wt.% L- ascobic acid, preferably from about 3 to 20 wt. % L-ascorbic acid, and more preferably about 5 to 10 wt% L-ascorbic acid in water and a carrier for topical application is disclosed. Such a composition appears to allow ready penetration into the skin and retards the damage caused by ultraviolet tight. Any composition containing at least about 1 wt. % L-ascorbic acid is expected to have beneficial effects, with the concentration of L-ascorbic acid being primarily limited by its solubility in the water/carrier system. The ratio of water to carrier is at least 1:1, and more preferably from 2:1 to 10:1, and the pH of the composition is no more than 3.0 to 3:5, preferably no more than about 2.5.

Une composition stable localisée est constituée essentiellement d'au moins environ 1 % du poids d'acide ascorbique L, et de préférence d'environ 3 à 20 % en poids d'acide ascorbique, et avantageusement de 5 à 10 % d'acide ascorbique L dans l'eau et d'un véhicule pour une application localisée. Une telle composition semble permettre une pénétration rapide dans la peau et retarde les dommages causés par la lumière ultraviolette. Toute composition comprenant au moins environ 1 % d'acide ascorbique est supposée avoir des effets bénéfiques, la concentration d'acide ascorbique L étant tout d'abord limitée par sa solubilité dans le système eau/véhicule. Le rapport eau/véhicule est au moins 1:1, et de préférence de 2:1 à 10:1, le pH de la composition ne dépasse pas 3,0 à 3,5, se situant préférablement au maximum aux environs de 2,5.

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