Stable bioactive somatotropins

Details Stable bioactive somatotropins Stable bioactive somatotropins

C - Chemistry, Metallurgy

07

K

530/13, 530/3.08

C07K 14/61 (2006.01) A61K 38/27 (2006.01) C07K 1/113 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339759

The present invention provides a stable and bioactive somatotropin which has its small-loop sulfhydryl groups derivatized and a method for producing the small-loop derivatized somatotropin. The small-loop derivatized somatotropin is stable during long term storage, i.e. it forms very few dimers, oligomers, and aggregates which inactivate the somatotropin, and has a bioactivity equal to or greater than that of the non-derivatized somatotropin.

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