Stable budesonide solutions, method of preparing them and...

A - Human Necessities – 61 – K

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A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 31/57 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2205305

The present invention relates to stable budeso- nide solutions with a pH of 6.0 or below, which are dissolved in water, alcohol or a water/alcohol mixture. These solutions preferably additionally contain sodium EDTA, cyclodextrin or mixtures thereof. The stable budesonide solutions according to the invention can be used for producing as enema or rectal foams.

L'invention concerne des solutions de budésonide stables, ayant un pH de 6,0 ou inférieur, dissoutes dans de l'eau, de l'alcool ou dans un mélange eau/alcool. Ces solutions contiennent en outre, de préférence, du sodium EDTA, de la cyclodextrine ou leurs mélanges. Ces solutions de budésonide stables s'utilisent pour préparer des lavements ou des mousses rectales.

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