Stable cell clone expressing a prion

Details Stable cell clone expressing a prion Stable cell clone expressing a prion

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2735774

The invention relates to a cell clone from the MovS6 cell line, said cell clone expressing a prion protein PrP and being capable of supporting the replication or the propagation of the pathological form PrPsc of said Prp, characterized in that it has a titer stability to at least the sixth passage in a marker for infection by a non-conventional transmissible agent (NCTA).

L'invention concerne un clone cellulaire issu de la lignée MovS6, ledit clone cellulaire exprimant une protéine prion PrP et étant capable de supporter la réplication ou la propagation de la forme pathologique PrPsc de ladite PrP, caractérisé en ce qu'il présente une stabilité du titre en marqueur de l'infection par un agent transmissible non conventionnel (ALNC) au moins jusqu'au 6ème passage.

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