Stable cell lines and methods for evaluating...

G - Physics – 01 – N

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G01N 33/50 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2669013

Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.

L'invention concerne des acides nucléiques et des vecteurs pour interférer avec l'expression de protéines de transports transmembranaires dans des cellules qui expriment de telles protéines. L'invention concerne également des cellules et des lignées cellulaires comprenant ces acides nucléiques et vecteurs. L'invention concerne également des procédés de criblage de produits chimiques et de biomolécules pour l'absorption gastro-intestinale chez des animaux, et des kits pour mettre en oeuvre de tels procédés.

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