Stable complexes of poorly soluble compounds

Details Stable complexes of poorly soluble compounds Stable complexes of poorly soluble compounds

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 9/14 (2006.01) A61K 31/715 (2006.01) A61K 31/78 (2006.01) A61K 31/785 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61K 47/48 (2006.01) C07C 231/22 (2006.01) C07C 233/81 (2006.01) C07C 303/42 (2006.01) C07C 311/49 (2006.01) C07D 239/62 (2006.01) C07D 487/04 (2006.01) C08B 3/16 (2006.01) C08B 11/04 (2006.01) C08B 11/193 (2006.01) C08F 8/32 (2006.01)

Patent

CA 2282906

Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50°. The compounds are microprecipitated in the ionic polymers in amorphous form. The complexes according to the present invention significantly increase the bioavailability of poorly soluble therapeutically active compounds.

Complexes stables et insolubles dans l'eau de composés peu solubles dont les molécules sont dispersées dans des polymères ioniques insolubles dans l'eau. Les polymères ioniques insolubles dans l'eau qui peuvent être utilisés ont une masse moléculaire supérieure à 80 000 Da et une température de transition vitreuse d'au moins 50 degrés. Les composés sont microprécipités dans les polymères ioniques sous forme amorphe. Ces complexes augmentent considérablement la biodisponibilité des composés thérapeutiques peu solubles.

Affiliated with

Also associated with

Rating

Stable complexes of poorly soluble compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable complexes of poorly soluble compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable complexes of poorly soluble compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1818121