Stable crystalline (6s)-and (6r)-tetrahydrofolic acid

Details Stable crystalline (6s)-and (6r)-tetrahydrofolic acid Stable crystalline (6s)-and (6r)-tetrahydrofolic acid

C - Chemistry, Metallurgy

07

D

C07D 475/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2148671

The invention relates to stable crystalline (6S)- and (6R)-tetrahydrofolic acid, to its use, and to a process for its preparation. Crystalline (6S)- and (6R)-tetra- hydrofolic acids are also pure and extremely stable. The substances, which are otherwise highly sensitive to oxidation, are absolutely inert even when exposed to air and elevated temperature without stabilizers being added. The crystallization process at a pH of 3.5 claimed for the preparation of crystalline (6S)-tetrahydrofolic acid and the crystallization process at a pH of 2 claimed for the preparation of crystalline (6R)-tetrahydrofolic acid are simple to carry out and very high-yielding.

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