A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/48
A61K 51/12 (2006.01)
Patent
CA 1114291
STABLE DIAGNOSTIC REAGENTS ABSTRACT OF THE DISCLOSURE The present specification discloses diagnostic reagents comprising a chelating agent and stannous tin which are suitable for conversion to radiopharmaceuticals by the addition of a radionuclide, such as suitable forms of technetium 99m, said reagents being stabilized against oxidation and/or hydrolysis by the addition thereto of from 1 to 100 moles, preferably 3 to 50 moles, of ascorbic acid, erythorbic acid, pharmaceutically acceptable inorganic salts thereof or mixtures thereof. Furthermore, the present specification discloses the radiopharmaceuticals obtained by labeling these stabilized reagents with a radionuclide and to a process for the manufacture of these stabilized reagents. The chelating agent may, for example, be selected from the groups consisting of ethane-1-hydroxy-1,1-diphosphonate, polyphosphate, dimercaptosuccinic acid, diethylaminetriamine pentaacetic acid, 2-mercaptoisoburyric acid, and human serum albumin.
249454
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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