C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/79 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2459269
The present invention provides a vector system which can be stably translocated from the cytoplasm of a cell to the nucleus where it is a stable nuclear episomal vector. A basic vector system according to the present invention is generally composed of nucleic acid encoding (a) a promoter functional both in cytoplasm and nucleus, operably linked to (b) a plasmid maintenance/translocation factor and (c) an origin of replication.
La présente invention concerne un système vecteur qui peut être transloqué de façon stable du cytoplasme d'une cellule au noyau où il constitue un vecteur épisomique nucléaire stable. Un système vecteur de base selon l'invention est généralement composé d'un acide nucléique codant (a) un promoteur fonctionnel à la fois dans le cytoplasme et dans le noyau, lié de façon fonctionnel à (b) un facteur de maintien/translocation du plasmide, et (c) d'une origine de réplication.
Wagner Thomas E.
Yu Xianzhang
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Ghc Research Development Corporation
Wagner Thomas E.
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