Stable fixed dose topical formulation

Details Stable fixed dose topical formulation Stable fixed dose topical formulation

A - Human Necessities

61

K

A61K 31/192 (2006.01) A61K 9/50 (2006.01) A61K 31/7042 (2006.01) A61P 17/10 (2006.01)

Patent

CA 2717899

The present invention relates to stable fixed dose topical formulations comprising an antiacne agent and an antibiotic, which exhibit storage stability at a temperature of about 40 °C and relative humidity of about 75 % for a period of at least 3 months. Particularly, the present invention relates to stable fixed dose topical formulations comprising therapeutically effective amounts of (a) adapalene-containing microspheres and (b) clindamycin, a process for their preparation thereof and their use for the treatment of acne.

Cette invention concerne des formulations topiques stables sous forme de doses fixes comprenant un anti-acnéique et un antibiotique, qui sont stables au stockage à une température d'environ 40 °C et à une humidité relative d'environ 75 % pendant une période d'au moins 3 mois. Cette invention concerne, en particulier, des formulations topiques stables sous forme de doses fixes comprenant des quantités thérapeutiquement efficaces de (a) microsphères contenant de l'adapalène et (b) clindamycine, ainsi qu'un procédé pour leur préparation et leur utilisation pour le traitement de l'acné.

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