Stable fixed-dose unitary formulations comprising tenofovir,...

Details Stable fixed-dose unitary formulations comprising tenofovir,... Stable fixed-dose unitary formulations comprising tenofovir,...

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 31/513 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2611523

In accordance with this invention a novel pharmaceutical product containing efavirenz, emtricitabine and tenofovir DF are provided as a multicomponent unitary oral dosage form, component 1 comprising tenofovir DF (and, optionally, emtricitabine) and component 2 comprising efavirenz, wherein components 1 and 2 are in a stabilizing configuration. In preferred embodiments component 1 is made by dry granulation.

Selon cette invention, un nouveau produit pharmaceutique contenant de l'efavirenz, de l'emtricitabine et du tenofovir DF est produit sous forme posologique orale unitaire à plusieurs composés, un composé 1 contenant du tenofovir DF (et, facultativement, de l'emtricitabine) et un composé 2 contenant de l'efavirenz, lesdits composés 1 et 2 présentant une configuration stabilisatrice. Dans des modes de réalisation préférés, le composé 1 est élaboré par granulation sèche.

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