Stable freeze-dried pharmaceutical formulation

Details Stable freeze-dried pharmaceutical formulation Stable freeze-dried pharmaceutical formulation

A - Human Necessities

61

K

A61K 47/26 (2006.01) A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2234140

A pharmaceutically acceptable freeze-dried formulation consisting of an amorphous phase and a crystalline phase and including at least one non-protein active principle. The formulation is characterised in that it contains mannitol and alanine in a ratio R of 0.1-1, where R is the weight of mannitol over the weight of alanine.

L'invention a pour objet une formulation lyophilisée constituée d'une phase amorphe et d'une phase cristalline, pharmaceutiquement acceptable comprenant au moins un principe actif non protéique, caractérisée en ce qu'elle contient du mannitol et de l'alanine dans un rapport R compris entre 0,1 et 1, R représentant la masse de mannitol sur la masse d'alanine.

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