A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/529 (2006.01) A61K 9/19 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2529598
A freeze drying preparation for injection containing in each dose 0.5 to 60~g tetrodotoxin or the analogs thereof, which has good stability and accords with human body safety, and can be long stored at room temperature. Said preparation also contains compounds which can reduce C1-4 hydroxy activity of tetrodotoxin or the analogs thereof, such as glucosidic linkage containing compounds selected from any one of disaccharide, polysaccharid, the derivatives thereof or their mixture, and auxiliary solvent which improves dissoving capacity of tetrodotoxin or the analogs thereof.
L'invention concerne une préparation lyophilisée destinée à être injectée, contenant dans chaque dose 0,5 à 60µg de tétrodotoxine ou d'analogues de celle-ci, possédant une bonne stabilité, ne nuisant pas à la santé, et présentant une durée de stockage élevée à température ambiante. Cette préparation contient également des composés pouvant réduire l'activité hydroxy C1-4 de la tétrodotoxine ou d'analogues de celle-ci, tels que des composés contenant une liaison glucosidique choisis parmi disaccharide, polysacharide, des dérivés de ceux-ci ou leur mélange, et un solvant auxiliaire améliorant la capacité de dissolution de la tétrodotoxine ou des analogues de celle-ci.
Huang Xiaoyan
Kang Yuhong
Zhang Xiao
Nanning Maple Leaf Pharmaceutical Co. Ltd.
Rapaport Lesley
Wex Medical Limited
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