Stable glycerin iodine concentrate compositions

A - Human Necessities – 61 – K

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A61K 33/18 (2006.01) A01N 25/22 (2006.01) A01N 59/12 (2006.01) A01P 1/00 (2006.01) A61K 47/10 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2285004

Stable aqueous glycerin iodine concentrates are provided which are adapted for dilution in water to yield germicidal iodine use solutions. The concentrates include from about 30-87 % by weight glycerin, from about 0.15-15 % by weight iodine, from about 0.15-15 % by weight iodide ion, and one or more additives such as compatible wetting agents, hydrotropes, thickening agents, additional emollients and buffering systems. The concentrates are stable for a period of at least about 3 months at room temperature and are dilutable at a ratio of 1 part concentrate with from about 2-80 parts water. The concentrates can be formulated to give very low free iodine values as concentrates, but provide dramatically increased free iodine values as diluted use solutions.

La présente invention concerne des concentrats d'iode glycérinée aqueux stables, adaptés à une dilution dans l'eau, de façon à donner des solutions utilisables d'iode germicide. Les concentrats comprennent environ 30-87 % en masse de glycérine, environ 0,15-15 % en masse d'iode, environ 0,15-15 % en masse d'ion d'iode, et un ou plusieurs additifs tels que des agents mouillants compatibles, des hydrotropes, des épaississants, des émollients supplémentaires et des systèmes tampons. Les concentrats sont stables pendant une période d'au moins 3 mois environ, à température ambiante. Ils peuvent être dilués à raison d'une part de concentré pour environ 2-80 parts d'eau. Ces concentrats peuvent être formulés de façon à donner des indices d'iode libre très faibles dans des concentrats, mais leurs indices d'iode libre augmentent de façon considérable dans des solutions utilisables en dilution.

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