A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/285
A61K 31/23 (2006.01) A61K 9/107 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01) A61K 47/44 (2006.01)
Patent
CA 1185185
Abstract of the Disclosure: A process for the preparation of .beta.-carotene micellar solutions, wherein a non-ionic emul- sifier which is suitable for the preparation of micellar solutions is heated at from 160 to 180°C and a total of from 20 to 30% by weight, based on the emulsifier, of .beta.-carotene is introduced in the presence of a conventional anti- oxidant, the hot homogeneous mixture is cooled rapidly to below 100°C by adding water, and the formulation is brought to the desired concentration of from 3 to 6% by weight by adding further water, and the .beta.-carotene micellar solutions obtained by this process. The non-ionic emulsifiers used in this process have an HLB value of from 12 to 16, and are in particular oxyethylated triglycerides of fatty acids of 12 to 18 carbon atoms con- taining 20 - 60 oxyethylene units. Parenteral adminis- tration of the stable .beta.-carotene micellar solutions according to the invention to cattle relieves the disturbed estrus cycle and impaired fertility caused by .beta.-carotene deficiency.
391630
Hoppe Peter P.
Schneider Joachim U.
Schulz Bernhard
Tiefenbacher Hubert
Basf Aktiengesellschaft
Robic Robic & Associes/associates
LandOfFree
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