Stable injectable solutions of vinca dimer salts

Details Stable injectable solutions of vinca dimer salts Stable injectable solutions of vinca dimer salts

A - Human Necessities

61

K

167/240

A61K 31/40 (2006.01) A61K 9/00 (2006.01) A61K 31/475 (2006.01) A61K 47/18 (2006.01)

Patent

CA 1303992

ABSTRACT A stable, injectable pharmaceutical composi- tion of vinca dimer salts. The compositions are in the form of an aqueous solution comprising per 1 ml of solution: from about 0.2 to about 2 mg of one or more pharmaceutically acceptable vinca dimer salts; from aobut 0.1 to about 1.0 mg of a pharma- ceutically acceptable ethylenediamine-tetra- acetic acid (EDTA) salt; acetate buffer in an amount necessary to maintain said aqueous solution at a pH of from about 3.0 to about 5.5; and from about 1.5 to about 2.5 mg of a preserva- tive selected from methyl paraben, propyl paraben and mixtures thereof.

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