A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/28 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2295140
The present invention provides a monomeric insulin analog formulation stabilized against aggregation in which the buffering agent is either TRIS or arginine. The stable formulations of the present invention are useful for treating diabetes, and are particularly advantageous in treatment regimes requiring lengthy chemical and physical stability, such as, in continuous infusion systems.
La présente invention concerne une formulation d'un analogue d'insuline monomère, stabilisée pour prévenir l'agrégation, le tampon de cette formulation étant soit un tampon Tris, soit de l'arginine. Les formulations stables de la présente invention sont utiles au traitement du diabète, et particulièrement efficaces dans les schémas de traitement nécessitant une stabilité chimique et physique durable desdites formulations, par exemple dans un système de perfusion continue.
Defelippis Michael Rosario
Dobbins Michael Allen
Frank Bruce Hill
Li Shun
Rebhun Dawn Marie
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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