Stable isotope labeling of paclitaxel

Details Stable isotope labeling of paclitaxel Stable isotope labeling of paclitaxel

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01)

Patent

CA 2409944

The present invention relates to isotopically labeled analogs of taxane molecules, which are synthetically formed to have incorporated therein at a selected position a stable isotope of an element existing at the selected position in the standard taxane molecule. The present invention also relates to methods of producing isotopically labeled taxane molecules, and methods of determining the retention of a target taxane in a biological material derived from an organism that has been dosed with the target taxane.

L'invention concerne des analogues de molécules de taxane, marqués de façon isotope et formés de manière synthétique pour comporter une incorporation, au niveau d'une position choisie, d'un isotope stable d'un élément existant au niveau de la position choisie dans la molécule standard de taxane. L'invention concerne également des procédés de production de molécules de taxane, marquées de façon isotope, ainsi que des procédés de détermination de la rétention d'un taxane cible dans un matériau biologique dérivé à partir d'un organisme qui a reçu une dose du taxane cible.

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