Stable lipid-comprising drug delivery complexes and methods...

Details Stable lipid-comprising drug delivery complexes and methods... Stable lipid-comprising drug delivery complexes and methods...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2211118

Novel stable, concentrated, biologically active and ready-to-use lipid- comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the components of the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

L'invention concerne de nouveaux complexes stables d'administration de médicaments comprenant des lipides concentrés, biologiquement actifs et prêts à l'emploi, ainsi que leur procédé de production. L'acitivité biologique des complexes produits est comparable aux formulations préparées selon le procédé de mélange actuel et lors d'une purification, les complexes produits par le procédé de cette invention sont 50 à 100 fois plus concentrés que les constituants des complexes formés par mélange. Le procédé décrit dans cette invention permet une production à grande échelle de systèmes d'administration de médicaments comprenant des lipides, utiles en thérapie génique ainsi que dans d'autres applications.

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