A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 6/00 (2006.01)
Patent
CA 2609579
The present invention relates to a stable liquid formulation comprising desoximetasone, isopropyl myristate, a C2-C4 alcohol and a stabilizing agent. Specifically, the present invention provides a liquid formulation comprising: a) about 0.01 wt % to about 2.5 wt % desoximetasone; b) about 10 wt % to about 70 wt % isopropyl myristate; c) about 20 wt % to about 70 wt % C2-C4 alcohol; and d) a stabilizing agent selected from the group consisting of an oleaginous vehicle and a propellant, wherein the stabilizing agent is in an amount sufficient to reduce the formation of less than about 1 wt % 17-carboxy- 9.alpha.-fluoro-11~-hydroxy-16a-methyl-androsta-1,4-diene-3-one under an accelerated storage condition.
L'invention concerne une préparation liquide stable comprenant de la désoxymétasone, du myristate isopropylique, un alcool C2-C4 et un agent stabilisant. L'invention porte spécifiquement sur une préparation liquide comprenant : a) environ 0,01 % en poids à environ 2,5 % en poids de désoximétasone ; b) environ 10 % à environ 70 % en poids de myristate isopropylique ; c) environ 20 % en poids à environ 70 % en poids d'alcool C2-C4 ; et d) un agent stabilisant choisi dans le groupe formé d'un véhicule oléagineux et d'un propulseur, la quantité d'agent stabilisant étant suffisante pour réduire la formation de moins d'environ 1 % en poids de 17-carboxy-9.alpha.-fluoro-11.beta.-hydroxy-16.alpha.- méthyl-androsta-1,4-diène-3-one dans des conditions de stockage accélérées.
Bailey Arthur
Dixit Suresh
Rao Srinvisa
Yacobi Avraham
Johnston Wassenaar Llp
Taro Pharmaceuticals North America Inc.
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