Stable liquid formulations of plasmid dna

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 1/06 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2579340

This invention relates to plasmid DNA liquid formulations that are stable and stays un-degraded at +4~C to room temperature for long periods of time, and are thus useful for storage of plasmid DNA that are used research, plasmid- based therapy, such as DNA vaccine and gene therapy. The present invention also relates to a method of preserving plasmid DNA in a stable form over time at +4~C to room temperature. The present invention also relates to stable plasmid DNA liquid compositions for use in a method of treatment of the human or animal body by plasmid-based therapy, such as DNA vaccination or gene therapy.

L'invention concerne des préparations liquides d'ADN plasmidique stables, qui ne sont pas endommagées lorsqu'elles sont conservées à une température ambiante de +4 °C pendant de longues durées, et qui peuvent donc être utilisées dans le stockage d'ADN plasmidique utilisé dans la recherche ou dans les traitements à base de plasmides, tels que les vaccins à ADN et la thérapie génique. L'invention concerne également un procédé de conservation d'ADN plasmidique dans une forme stable sur la durée, à une température ambiante de +4 °C. L'invention concerne également des compositions liquides d'ADN plasmidique stables destinées à être utilisées dans un traitement à base de plasmides administré à un animal ou à un humain, tel qu'une vaccination à ADN ou une thérapie génique.

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