Stable lyophilized anthracycline glycosides

Details Stable lyophilized anthracycline glycosides Stable lyophilized anthracycline glycosides

A - Human Necessities

61

K

A61K 9/19 (2006.01) A61K 9/08 (2006.01) A61K 31/704 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2606390

The present invention provides lyophilized and stable lyophilized anthracycline glycoside salts, in particular, the hydrochloride salt. Also, the present invention provides methods of stabilizing these anthracycline glycoside salts, and methods for producing stable lyophilized anthracycline glycoside salts, such as for example the antineoplastic compound idarubicin hydrochloride, or the compounds doxorubicin hydrochloride, and epirubicin hydrochloride.

L'invention concerne des sels de glycosides d'anthracycline lyophylisés stables, notamment les sels de chlorhydrate. L'invention concerne également des procédés de stabilisation de sels de glycosides d'anthracycline et des procédés de fabrication de sels de glycosides d'anthracycline lyophylisés stables, par exemple le composé antinéoplasique chlorhydrate d'idarubicine ou les composés chlorhydrate de doxorubicine et chlorhydrate d'épirubicine.

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