Stable, nasally, orally or sublingually applicable...

A - Human Necessities – 61 – K

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Details

A61K 38/11 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2399822

The invention relates to a stable, nasally, orally or sublingually applicable pharmaceutical preparation for administering to patients. The inventive preparation has an aqueous solution of desmopressin as the active agent. Said solution contains an osmoticum and a buffer which maintains the pH-value in the range of 4 to 6, preferably about 5. The buffer is malic acid, preferably in the form of a racemate. An improved stability of the desmopressin content in the preparation is thus obtained.

La présente invention concerne une préparation pharmaceutique stable, qui peut être utilisée par voie nasale, orale ou sublinguale et est destinée à des patients. La substance active de cette préparation est une solution aqueuse de desmopressine. Cette solution contient un agent osmotique et un tampon qui maintient le pH entre 4 et 6, de préférence à environ 5. Le tampon est de l'acide malique, se présentant de préférence sous forme d'un mélange racémique. Cette invention permet d'obtenir une meilleure stabilité de la teneur en desmopressine de ladite préparation.

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