Stable near-infrared (nir) marker dyes based on...

C - Chemistry – Metallurgy – 09 – B

Patent

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C09B 23/02 (2006.01) C09B 23/01 (2006.01) C12Q 1/68 (2006.01) G01N 33/533 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2380272

The invention relates to so-called laser-compatible NIR marker dyes based on polymethines for use in optical, in particular, fluorescence optical determination and detection methods, for example, in the fields of medicine, pharmaceutics and in the areas of life science, materials science and environmental science. The aim of the invention was to create NIR marker dyes based on polymethine which have a high degree of photostability and stability in storage as well as a high fluorescent yield and which can be excited to fluorescence in the easiest possible manner by means of laser radiation in the visible or NIR spectral range, particularly with light of an argon, helium/neon, or diode laser. According to the invention, dyes based on polymethines of general formula (I) are used.

L'invention concerne ce qu'il convenu d'appeler des colorants marqueurs du domaine du proche infrarouge, laser-compatibles, à base de polyméthines, s'utilisant dans des procédés de détermination et de détection optiques, notamment par fluorescence optique, par exemple dans le domaine médical, pharmaceutique, ainsi qu'en biologie, en sciences des matériaux et en écologie. L'invention vise à mettre au point des colorants marqueurs du domaine du proche infrarouge à base de polyméthine très photostables et très stables au stockage, ainsi qu'à rendements fluorescents élevés, pouvant être excités en fluorescence de la manière la plus simple possible par rayonnement laser dans le domaine spectral visible ou du proche infrarouge, notamment avec la lumière d'un laser à argon, à hélium/néon ou à diode. Selon l'invention, on utilise des colorants à base de polyméthine de formule générale (I).

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