C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 381/00 (2006.01) A61K 31/095 (2006.01) A61L 2/18 (2006.01) A61L 2/20 (2006.01) A61L 2/23 (2006.01) A61L 29/16 (2006.01)
Patent
CA 2335989
Disclosed are novel NO-releasing compounds which comprise a stabilized S- nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.
L'invention concerne des composés à libération de NO qui renferment un groupe S-nitrosyle stabilisé et un groupe alcool libre ou thiol libre. L'invention concerne également un procédé relatif à l'élaboration desdits composés, qui consiste à faire réagir un polythiol ou un thioalcool avec un agent de nitrosylation. L'invention concerne en outre des dispositifs médicaux revêtus de ces composés, des procédés qui permettent d'assurer la libération de NO sur des sites de traitement chez un patient, en utilisant les dispositifs médicaux considérés, et des procédés relatifs à la stérilisation de surfaces.
Stamler Jonathan S.
Toone Eric J.
Duke University Medical Center
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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