Stable non-dihydrate azithromycin oral suspensions

Details Stable non-dihydrate azithromycin oral suspensions Stable non-dihydrate azithromycin oral suspensions

A - Human Necessities

61

K

A61K 31/7048 (2006.01) A61K 9/00 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2591744

This invention relates to a powder for oral suspension, and an oral suspension made there from, which comprises non-dihydrate azithromycin and an azithromycin conversion stabilizing excipient, wherein said excipient reduces the conversion of the form of azithromycin, when placed in suspension, to another form of azithromycin. This invention further relates to a method for reducing the conversion of a form of non-dihydrate azithromycin, in an oral suspension, by including at least one cyclodextrin in said oral suspension.

La présente invention concerne une poudre destinée à une suspension orale et une suspension orale formée à partir de cette dernière, qui comprend de l'azithromycine non dihydrate et un excipient stabilisant la conversion de l'azithromycine, ledit excipient réduisant la conversion de la forme d'azithromycine, une fois placée en suspension, en une autre forme d'azithromycine. Cette invention se rapporte également à une méthode de réduction de la conversion d'une forme d'azithromycine non dihydrate, dans une suspension orale, au moyen de l'incorporation d'au moins une cyclodextrine dans ladite suspension orale.

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