Stable oxapenem-3-carboxylic acids as -lactamase inhibitors

Details Stable oxapenem-3-carboxylic acids as -lactamase inhibitors Stable oxapenem-3-carboxylic acids as -lactamase inhibitors

C - Chemistry, Metallurgy

07

D

167/187, 260/299

C07D 503/00 (2006.01) A61K 31/42 (2006.01)

Patent

CA 2000058

Abstract A pharmaceutical preparation comprising an antibiotic, a pharmaceutical excipient therefor, and in addition an oxapenem-3-carboxylic acid of the formula Image or a pharmaceutically acceptable salt, ester or amide in which R1 and R2 each independently is hydrogen or a pharmaceutically acceptable group having to 10 carbon atoms which is connected with the balance of the molecule via carbon-carbon single bonds, and in which R3, R4 and R5 each independently is a pharmaceutically acceptable group having 1 to 10 carbon atoms which is connected with the balance of the molecule via carbon-carbon single bonds. Le A 26 194

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