Stable pegylated interferon formulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/19 (2006.01) A61K 38/21 (2006.01) A61K 47/26 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2576549

The present invention relates to lyophilized formulations of pegylated interferon which are prepared using trehalose as a cryoprotectant. The formulations have a low moisture content, which helps stabilize the pegylated interferon during storage of the formulations at room temperature. In addition, methods for preparing these formulations are provided.

La présente invention concerne des préparations lyophilisées d'interféron pegylé dans lesquelles on utilise du tréhalose comme cryoprotecteur. Ces préparations présentent une faible teneur en eau et contribuent à stabiliser l'interféron pegylé pendant le stockage à température ambiante. Sont également décrites des méthodes de fabrication de ces préparations.

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