Stable polymorph of bifeprunox...

Details Stable polymorph of bifeprunox... Stable polymorph of bifeprunox...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4985 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2536149

The invention relates to a stable polymorphic form of the compound 7-[4-([1,1'-biphenyl] -3-ylmethyl)-l -piperazinyl]­2(3H)-benzoxazolone monomethanesulfonate (INNM bifeprunox mesylate), a method for the preparation of said polymorphic form and its use in pharmaceutical products, especially in pharmaceutical products for the treatment of psychotic disorders and Parkinson's disease.

La présente invention concerne une forme polymorphe stable du composé 7-[4-([1,1'-biphényl] -3-ylméthyl)-l -pipérazinyl]-2(3H)-benzoxazolone monométhanesulfonate (INNM biféprunox mésylate), un procédé de préparation de ladite forme polymorphe et son utilisation dans des produits pharmaceutiques, notamment dans des produits pharmaceutiques destinés au traitement des troubles psychotiques et de la maladie de Parkinson.

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