Stable prostaglandin-containing compositions

A - Human Necessities – 61 – K

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Details

A61K 9/00 (2006.01) A61K 31/557 (2006.01)

Patent

CA 2595237

A pharmaceutical composition containing a prostaglandin and an alkanoic acid ester of a polyethoxylated sorbitol in an amount effective to enhance the chemical stability of the prostaglandin, and the use thereof for treating ophthalmic conditions. Also disclosed are methods for enhancing the chemical stability of a prostaglandin-containing composition by using an alkanoic acid ester of a polyethoxylated sorbitol.

L'invention concerne une composition pharmaceutique qui contient une prostaglandine et un ester d'acide alcanoïque d'un sorbitol polyéthoxylé dans des proportions capables d'améliorer la stabilité chimique de la prostaglandine, ainsi que l'utilisation de cette composition pour traiter des états ophtalmiques. Par ailleurs, l'invention concerne des procédés d'amélioration de la stabilité chimique d'une composition contenant de la prostaglandine au moyen d'un ester d'acide alcanoïque d'un sorbitol polyéthoxylé.

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