Stable protein: phospholipid compositions and methods

Details Stable protein: phospholipid compositions and methods Stable protein: phospholipid compositions and methods

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/127 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2150939

The invention relates to stable compositions of proteins and related methods wherein a protein capable of transitioning into the molten globular state is contacted with a negatively charged lipid vesicle, thereby stabilizing the protein against thermally-induced aggregation, denaturation, and loss of activity. The protein: phospholipid complex directly stabilizes the secondary and tertiary structure of the protein, and the compositions are useful in high temperature formulations and in novel delivery vehicles.

L'invention concerne des compositions stables de protéines et des procédés correspondants dans lesquels une protéine pouvant effectuer une transition vers l'état globulaire fondu est mise en contact avec une vésicule de lipide chargée négativement, ce qui stabilise la protéine contre une agrégation provoquée thermiquement, une dénaturation et une perte d'activité. Le complexe protéines-phospholipides stabilise directement la structure secondaire et tertiaire de la protéine et de telles compositions sont efficaces dans des formulations à température élevée et dans de nouveaux véhicules d'administration.

Affiliated with

Also associated with

Rating

Stable protein: phospholipid compositions and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable protein: phospholipid compositions and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable protein: phospholipid compositions and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1651744