Stable radiopharmaceutical compositions and methods for...

A - Human Necessities – 61 – K

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A61K 51/00 (2006.01)

Patent

CA 2526556

Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds, and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor).

L'invention concerne des formulations radiopharmaceutiques stabilisées. L'invention concerne des méthodes de fabrication et d'utilisation de formulations radiopharmaceutiques stabilisées. L'invention concerne des méthodes de fabrication et d'utilisation de formulations radiopharmaceutiques stabilisées. L'invention concerne également des stabilisateurs permettant d'améliorer la radiostabilité de composés radiothérapeutiques et radiodiagnostiques, et des formulations les contenant. En particulier, l'invention concerne des stabilisateurs utiles pour la préparation et pour la stabilisation de composés radiodiagnostiques et radiothérapeutiques ciblés, et dans un mode préféré de réalisation, l'invention concerne la préparation et la stabilisation de composés radiodiagnostiques et radiothérapeutiques qui sont ciblés sur le récepteur peptidique de libération de gastrine (récepteur GRP).

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