Stable recombinant adenosine deaminase

Details Stable recombinant adenosine deaminase Stable recombinant adenosine deaminase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 38/50 (2006.01) A61K 47/48 (2006.01) C12N 9/78 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2684750

A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized recombinant adenosine deaminase, polymer conjugates and methods of treatment using the same are also disclosed.

L'invention concerne une adénosine désaminase recombinante de mutéine ayant tout résidu cystéine oxydable remplacé par un résidu d'acide aminé non oxydable. L'adénosine désaminase recombinante stabilisée, des polymères conjugués et des procédés de traitement les utilisant sont également décrits.

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