C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/06 (2006.01) A61K 31/205 (2006.01) A61K 31/415 (2006.01) C07C 229/26 (2006.01) C07D 233/64 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2104372
2104372 9313056 PCTABS00024 The novel salts of (+)-(1S,2R)-2-[[N-(2-hydroxylamino-2-oxoethyl)-N-methyl-amino]carbonyl]cycloh_ exane-1-carboxylic acid with metals and organic bases, represented by general formula (I) wherein R and R' if taken together represent a bivalent cation selected from calcium, ethylene diamine and other pharmaceutically acceptable cations or organic bases, or if R' = H+, R represents sodium, potassium, an imidazole group, lysine, choline, diethanolamine, arginine, or histidine, possess ACE-inhibitory activity and are therefore useful as active ingredients of antihypertensive drugs. The process for their preparation preferably entails the reaction of the starting acid, protected with a benzyl group, with the suitable hydrate, carbonate or organic base in hydrogenation conditions in the presence of a hydrogenation catalyst.
Giorgi Raffaello
Subissi Alessandro
Turbanti Luigi
Laboratori Guidotti S.p.a.
Riches Mckenzie & Herbert Llp
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