Stable solid preparation containing 4,5-epoxymorphinan...

Details Stable solid preparation containing 4,5-epoxymorphinan... Stable solid preparation containing 4,5-epoxymorphinan...

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61P 11/14 (2006.01) A61P 17/04 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2685131

Disclosed is a stable solid preparation comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an active ingredient. Specifically disclosed is a stable solid preparation comprising: a 4,5-epoxymorphinan derivative represented by the general formula (I) or a pharmacologically acceptable acid addition salt thereof as an active ingredient; sodium thiophosphate; a sugar or a sugar alcohol; and a hydroxypropylcellulose having a low degree of substitution in an amount of 1 to 30% by weight per unit weight of the total amount of the active ingredient, sodium thiophosphate and the sugar or the sugar alcohol.

L'invention porte sur une préparation solide stable comprenant un dérivé de 4,5-époxymorphinane ou un sel d'addition avec les acides, pharmacologiquement acceptable, de celui-ci comme principe actif. De façon spécifique, l'invention porte sur une préparation solide stable comprenant : un dérivé de 4,5-époxymorphinane représenté par la formule générale (I) ou un sel d'addition avec les acides, pharmacologiquement acceptable, de celui-ci comme principe actif ; du thiophosphate de sodium ; un sucre ou un alcool de sucre ; et une hydroxypropylcellulose ayant un faible degré de substitution dans une quantité de 1 à 30 % en poids par unité de poids de la quantité totale de l'ingrédient actif, du thiophosphate de sodium et du sucre ou de l'alcool de sucre.

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