Stable sulpho-adenosyl-l-methionine (same) salts,...

Details Stable sulpho-adenosyl-l-methionine (same) salts,... Stable sulpho-adenosyl-l-methionine (same) salts,...

C - Chemistry, Metallurgy

07

H

195/120, 260/229

C07H 19/16 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1241285

ABSTRACT The present invention relates to new stable sulpho-adenosyl-L- methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles. Said salts correspond to the general formula: SAMe.n(CH2)m(SO3H)2 (I) where n can vary from 1 to 2 and m can vary from 3 to 12. The process for producing said salts consists of the following stages: a) enriching the starting yeast with SAMe; b) lysing the cells and recovering a solution rich in SAMe (cell lysate); c) prepurifying the cell lysate by ultrafiltration d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; e) passing the eluate of said column through a column of absorption resin and washing with the required disulphonic acid; f) concentrating the eluate of the latter column by reverse osmosis; g) drying the concentrated solution.

481416

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