Stable topical compositions for 1,2,4-thiadiazole derivatives

Details Stable topical compositions for 1,2,4-thiadiazole derivatives Stable topical compositions for 1,2,4-thiadiazole derivatives

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 9/00 (2006.01) A61K 31/433 (2006.01) A61P 17/00 (2006.01) A61P 17/10 (2006.01)

Patent

CA 2759730

The present application provides a stable topical composition comprising a compound of 1,2,4-thiadiazole derivatives and the related thiourea derivatives. The stable topical composition may be present in various forms, including aqueous gel, cream, and emulsion. The stable topical composition may be stored at refrigerated or ambient condition for a reasonable shelf-life. The present application also provides a method of treating dermato logic disorders mediated by a melanocortin receptor using the stable topical composition. The stable composition may be delivered using a single chamber or dual chamber device. A method of preparing and delivering the stable composition is also provided.

La présente invention porte sur une composition topique stable comprenant un composé de dérivé de 1,2,4-thiadiazole et les dérivés apparentés de la thio-urée. La composition topique stable peut se présenter sous différentes formes, parmi lesquelles un gel aqueux, une crème et une émulsion. La composition topique stable peut être stockée dans des conditions réfrigérées ou dans des conditions ambiantes, pour une durée de conservation raisonnable. La présente invention porte aussi sur un procédé de traitement de troubles dermatologiques à médiation par un récepteur de la mélanocortine, à l'aide de la composition topique stable. La composition stable peut être administrée à l'aide d'un dispositif à compartiment unique ou à double compartiment. L'invention porte également sur un procédé de préparation et d'administration de la composition stable.

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