A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/24 (2006.01) A61K 31/047 (2006.01) A61K 31/351 (2006.01) A61K 31/7048 (2006.01)
Patent
CA 2724971
The present invention describes a standardized extract obtained from the leaves of Hancornia speciosa Gomes (EHS), popularly known as "mangaba" in Brazil, as well as a standardized fraction with inhibiting activity on the angiotensin converting enzyme (ACE), and vasodilating, anti-hypertensive and antioxidant properties. The invention further relates to the preparation of pharmaceutical compositions that contain said extract or fractions derived from the extract of Hancornia speciosa Gomes leaves rich in cyclitols and flavonoids, as well as the use of same for the treatment of cardiovascular disorders such as arterial hypertension, atherosclerosis, stenosis, and non-limiting cardiac or cerebral ischaemia.
A presente invenção descreve a obtenção de um extrato padronizado de folhas de Hancomia speciosa Gomes (EHS), vulgarmente denominada "mangaba", e de uma fração padronizada com atividades inibidora da enzima conversora de angiotensina (ECA), vasodilatadora, anti-hipertensiva e antioxidante. A invenção compreende, ainda, a obtenção composições farmacêuticas que contem o extrato ou frações derivadas do extrato de folhas da espécie Hancomia speciosa Gomes ricas em ciclit?is e flavon?ides, bem como sua utilização para o tratamento de dist?rbios cardiovasculares como hipertensão arterial, aterosclerose, restenose, isquemia cardiaca ou cerebral não limitantes.
Caroline Da Silva Grazielle
Castro Braga Fernão
Coutinho Endringer Denise
de Franca Cortes Steyner
Gowling Lafleur Henderson Llp
Universidade Federal de Minas Gerais-Ufmg
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