Standardized extract and fraction from hancornia speciosa...

A - Human Necessities – 61 – K

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Details

A61K 36/24 (2006.01) A61K 31/047 (2006.01) A61K 31/351 (2006.01) A61K 31/7048 (2006.01)

Patent

CA 2759877

The present invention describes a standardized extract obtained from the leaves of Hancornia speciosa Gomes (EHS), popularly known as "mangaba" in Brazil, as well as a standardized fraction with inhibiting activity on the angiotensin converting enzyme (ACE), and vasodilating, anti-hypertensive and antioxidant properties. The invention further relates to the preparation of pharmaceutical compositions that contain said extract or fractions derived from the extract of Hancornia speciosa Gomes leaves rich in cyclitols and flavonoids, as well as the use of same for the treatment of cardiovascular diseases such as arterial hypertension, atherosclerosis, stenosis, and non-limiting cardiac or cerebral ischaemia.

La présente invention concerne l'obtention d'un extrait normalisé de feuilles de Hancornia speciosa Gomes (EHS), espèce vulgairement connue sous le nom de "mangaba", ainsi qu'une fraction normalisée présentant une activité inhibitrice de l'enzyme de conversion de l'angiotensine (ECA), une activité vasodilatatrice, une activité antihypertensive et une activité antioxydante. L'invention concerne également l'obtention de compositions pharmaceutiques contenant cet extrait ou des fractions dérivées de l'extrait de feuilles de l'espèce Hancornia speciosa Gomes riches en cyclitols et en flavonoïdes, ainsi que leur utilisation pour le traitement d'affections cardiovasculaires telles que l'hypertension artérielle, l'athérosclérose, la resténose ainsi que l'ischémie cardiaque ou cérébrale, entre autres.

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