Staphylococcus antigen and vaccine

Details Staphylococcus antigen and vaccine Staphylococcus antigen and vaccine

A - Human Necessities

61

K

A61K 39/085 (2006.01) A61K 39/40 (2006.01) A61M 25/00 (2006.01) C07K 4/04 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2366433

A negatively-charged Staphylococcus antigen contains amino acids and a N- acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of Staphylococcus, including S. epidermidis, S. haemolyticus and S. hominis. Staphylococcus strains that carry the antigen include many clinically significant strains of Staphylococcus. The antigen and antibodies to the antigen are useful in kits and assays for diagnosing Staphylococcus infection. Vaccines of the antigen and of whole cells that carry the antigen are also disclosed.

Cette invention concerne un antigène de Staphylococcus à charge négative qui contient des acides aminés et une hexosamine N-acétylée comme composante glucidique majeure. Cet antigène est commun à de nombreuses souches coagulase-négatives de Staphylococcus, dont des souches de S. epidermidis, S. haemolyticus, S. hominis. Les souches de Staphylococcus qui portent l'antigène renferment de nombreuses souches cliniquement significatives de Staphylococcus. L'antigène et les anticorps de l'antigène conviennent sous forme de kits et de bioanalyses pour le diagnostic de l'infection par le Staphylococcus. L'invention concerne également des vaccins de l'antigène et de cellules entière portant cette antigène.

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