Staphylococcus aureus antigen-containing whole cell vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/085 (2006.01) A61K 39/385 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2372633

A negatively-charged S. aureus antigen contains .beta.-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant strains of S. aureus that are not Type 5 or Type 8 strains. The antigen can be used in combination with S. aureus Type 5 polysaccharide antigen and S. aureus Type 8 polysaccaride antigen to provide nearly 100% coverage of S. aureus infection. The antigen and antibodies to the antigen are useful in kits and assays for diagnosing S. aureus infection. A whole cell vaccine of cells that contain the antigen is particularly useful in the treatment of mastitis.

L'invention concerne un antigène de <i>S.aureus</i> chargé négativement qui contient de la beta -hexosamine en tant que composant glucidique principal. Les souches de <i>S.aureus</i> qui transportent cet antigène représentent pratiquement l'ensemble des souches de <i>S.aureus</i> présentant une importance d'un point de vue clinique, qui ne sont pas des souches de Type 5 ou de Type 8. Cet antigène peut être utilisé en association avec l'antigène polysaccharidique de Type 5 de <i>S.aureus</i> et l'antigène polysaccharidique de Type 8 de <i>S.aureus</i> pour assurer une protection pratiquement à 100 % contre les infections par <i>S.aureus</i>. Un vaccin à cellules entières contenant cet antigène est particulièrement utile pour le traitement des mammites.

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