C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 31/16 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2241105
An isolated and purified Staphylococcus aureus Coenzyme A disulfide reductase (CoADR) is provided. Oligonucleotides encoding the CoADR, vectors and host cells containing such oligonucleotides are also provided. In addition, antibodies reactive with the CoADR are provided, as are methods of isolating the CoADR, producing recombinant CoADR, using CoADR for screening compounds for CoADR-modulating activity, and detecting S. aureus in a test sample.
L'invention se rapporte à la réductase de bisulfure de la coenzyme A (CoADR), isolée et purifiée, de Staphylococcus aureus, ainsi qu'à des oligonucléotides codant CoADR, à des vecteurs et des cellules hôtes contenant ces oligonucléotides. L'invention se rapporte également à des anticorps réagissant à CoADR, ainsi qu'à des procédés d'isolation de CoADR, de production de CoADR de recombinaison, utilisant CoADR dans le criblage de composés en vue de rechercher l'activité modulatrice de CoADR, et de détection de S.aureus dans un échantillon test.
Davies Julian E.
Delcardayre Stephen B.
Swabey Ogilvy Renault
The University Of British Columbia
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