Staphylococcus aureus exopolysaccharide and process

Details Staphylococcus aureus exopolysaccharide and process Staphylococcus aureus exopolysaccharide and process

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/085 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2469132

A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly- 1,6,.beta.-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.

La présente invention concerne un antigène d'adhésine intracellulaire (SAE) à structure de polysaccharide de masse moléculaire élevée. Cet antigène présente la structure générale d'un poly- 1,6,.beta.-2-amidoglucopyranoside, laquelle structure est substituée de façon variable avec des substituants N-acétyle et O-succinyle. L'invention concerne également un procédé permettant d'isoler du staphylocoque doré cet antigène. Ce SAE peut s'utiliser dans un vaccin, seul, mais aussi en conjugaison avec une protéine immunogène, et/ou avec un adjuvant immunogène.

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