Staphylococcus aureus protein staau_r2, gene encoding it and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/01 (2006.01) A01N 63/02 (2006.01) A01P 1/00 (2006.01) A61K 39/085 (2006.01) A61L 2/16 (2006.01) A61P 31/04 (2006.01) C07K 14/31 (2006.01) C12N 15/31 (2006.01) C12N 15/34 (2006.01) G01N 33/53 (2006.01) G01N 33/542 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2428595

This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to specific interaction between the S. aureus STAAU_R2 related protein or specific regions thereof, and growth-inhibitory proteins encoded by the S. aureus bacteriophage genome. The invention relates to the use of these interaction target sites as the basis of drug screening assays.

La présente invention concerne des polynucléotides et polypeptides récemment identifiés, leur production et leurs utilisations, ainsi que leurs variantes, agonistes et antagonistes et leurs utilisations. En particulier, cette invention a trait à l'interaction spécifique entre la protéine liée à <i>S. aureus</i> STAAU_R2 ou des zones spécifiques de celle-ci, et des protéines inhibitrices de croissance codées par le génome bactériophage <i>S. aureus</i>. Cette invention concerne également l'utilisation de ces sites d'interaction cible en tant que base d'essais de criblage de produits pharmaceutiques.

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