Staphylococcus aureus-specific antibody preparations

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) A61P 37/00 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2760493

A new antibody-based strategy for treating or preventing Staphylococcus aureus infections utilizes IgM antibodies specific for one or more Staphylococcus aureus capsular antigens. Examples of such antibodies include (i) a polyclonal IgM antibody composition that is isolated from pooled donor plasma and enriched for those IgMs that specifically bind Staphylococcus aureus capsular antigens or (ii) one or more IgM monoclonal antibodies that specifically bind Staphylococcus aureus capsular antigens.

L'invention porte sur une nouvelle stratégie à base d'anticorps pour traiter ou prévenir des infections par Staphylococcus aureus, qui utilisent des anticorps IgM spécifiques pour un ou plusieurs antigènes capsulaires de Staphylococcus aureus. Des exemples de tels anticorps comprennent (i) une composition d'anticorps IgM polyclonaux qui est isolée à partir d'un plasma de donneur rassemblé et enrichie pour ces IgM qui se lient spécifiquement à des antigènes capsulaires de Staphylococcus aureus ou (ii) un ou plusieurs anticorps monoclonaux IgM qui se lient spécifiquement à des antigènes capsulaires de Staphylococcus aureus.

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