Starch-pomegranate juice complex as an hiv entry inhibitor...

Details Starch-pomegranate juice complex as an hiv entry inhibitor... Starch-pomegranate juice complex as an hiv entry inhibitor...

A - Human Necessities

61

K

A61K 36/185 (2006.01) A61K 47/36 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2579055

A complex comprising a starch and an active anti~HIV-1 or anti-HIV-2 ingredient of pomegranate juice that is adsorbed on the starch when the starch is in a water insoluble form. The complex inhibits HIV-1 or HIV-2 infection and blocks the binding of HIV-1 or HIV-2 to the CD4 receptor and the CCR5 and CXCR4 coreceptors. The complex is used in a method of preventing HIV-1 or HIV- 2 infection comprising administering to a mucous membrane of a human a pharmaceutically effective anti-HIV-1 or anti-HIV-2 amount of the complex.

L'invention concerne un complexe comprenant de l'amidon et un ingrédient actif anti-HIV-1 ou anti-HIV-2 de jus de grenade qui est adsorbé sur l'amidon, lorsque l'amidon est sous une forme insoluble dans l'eau. Le complexe inhibe l'infection HIV-1 ou HIV-2 et bloque la liaison de HIV-1 ou de HIV-2 au récepteur de CD4 et aux co-récepteurs de CCR5 et de CXVR4. Le complexe est utilisé dans un procédé de prévention de l'infection HIV-1 ou HIV-2, procédé consistant à administrer dans une membrane muqueuse d'un humain, une quantité anti-HIV-1 ou anti-HIV-2 pharmaceutiquement efficace du complexe.

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