Stat3 agonists and antagonists and therapeutic uses thereof

Details Stat3 agonists and antagonists and therapeutic uses thereof Stat3 agonists and antagonists and therapeutic uses thereof

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/00 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2421723

The present invention relates to methods of modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.

L'invention concerne des procédés de modulation, c.-à-d. ayant une action agoniste ou antagoniste sur l'activité de signalisation de Stat3 (transducteur de signal et activateur de transcription3), utiles en thérapie génique. L'inhibition et/ou l'activation de la signalisation de Stat3 constitue une méthode efficace de modulation de l'angiogenèse et de la réaction immunitaire pour traiter et/ou prévenir l'inflammation, les infections, les affections immunitaires et l'ischémie.

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